The CIO role expectations instrument: validation and model testing

The validation of IS instruments has not been given the attention that it deserves. This study uses component-based structural equation modelling (PLS/SEM) to investigate the psychometric properties and possible modelling of the CIO role expectations instrument based on data obtained from 174 Australian CIOs. Results show that the CIO role expectation instrument has exhibited solid validity and reliability indices despite some minor weaknesses. The results also demonstrate the possibility to model the constructs of this instrument in different null and hierarchical models, and the validity of this instrument to measure the CIO role in different types of industries not just the healthcare sector in which it was developed. The results provide support for CIO role theory on two central issues: (1) CIOs are fulfilling a configuration of roles not just one specific role (2) the CIO roles can be grouped into two major categories: supply side roles and demand side roles

Study of human lymphoblastoid cell lines in tissue culture

The properties and potential applications of human lymphoblastoid cell linen have been investigated. Buch lines have been established by others from Burkitt's lymphoma tissue, from leukaetnic patients, from those with infectious mononucleosis and latterly from healthy subjects. There is an association between EB virus (Herpes-like virus of Epstein and Barr) and the growth of human lymphob1astold cell lines in vitro. The same virus is linked sero-epidemiologically with Burkitt's lymphoma, nasopharyngeal carcinoma, infectious mononucleosis and a number of other diseases of man. The exact role of the virus both in vivo and in vitro is a matter of some controversy. Using a simple culture technique, 40 cell lines were established from the peripheral blood leukocytes of a diaqnostically rai3:»d group of patients, from normal cord blood and from one h althy adult. 25 of these cultures were initiated by adding EB virus (in the form of lethally irradiated cells of a virus-positive line) to the fresh blood leukocytes. Evidence from experiments of this type suggest that EB virus has a lyraphoproliferative action in vitro. The cell lines are morphologically etlmost indistinguishable. They resemble primitive cells of the lymphoid series and appear to have the property of indefinite growth in vitro. They include some phagocytic cells and immunoglobulins are released into the culture medium. Feu of the lines were chromosomally abnormal when examined shortly after establishment but all of those examined after more than 1 year of continuous growth had abnormal karyotypes. There was no evidence for the recurrence of any specific chromosome aberration in a significant proportion of the lines. Antigenleally the established lines differ from the original donor's fresh lymphocytes. This is shown by measurement of tritiated thymidine uptake by lymphocytes exposed in vitro to irradiated cells from an autochthonous line. Together with the activation process, the fresh lymphocytes acquire cytotoxic potential directed specifically against the cell line used in the activation phase. Tt is suggested that this system constitutes a model for an immunological surveillance mechanism operating in vivo to eliminate deviant cells. Cell lines of this type offer rcone for detailed investiga¬ tion of the induction of proliferation in human tissue (in this case probably by FB virus) and of the immunological processes by which altered autochthonous cells may be recognised and destroyed. Both of these topics are relevant to the basic study of malignant disease. The prolonged life span and relative stability of these lines in vitro also presents opportunities in the Field of human genetics, both for the investigation of inherited disorders of man and, experimentally, for the measurement of spontaneous and induced mutation rates, analysis of gene linkage and chromosome mapping

Tuneable quantum interference in a 3D integrated circuit

Integrated photonics promises solutions to questions of stability, complexity, and size in quantum optics. Advances in tunable and non-planar integrated platforms, such laser-inscribed photonics, continue to bring the realisation of quantum advantages in computation and metrology ever closer, perhaps most easily seen in multi-path interferometry. Here we demonstrate control of two-photon interference in a chip-scale 3D multi-path interferometer, showing a reduced periodicity and enhanced visibility compared to single photon measurements. Observed non-classical visibilities are widely tunable, and explained well by theoretical predictions based on classical measurements. With these predictions we extract a Fisher information approaching a theoretical maximum, demonstrating the capability of the device for quantum enhanced phase measurements.Comment: 11 pages, 24 figure

Bis(2-acetylpyridine-κ2 N,O)silver(I) tetra­fluoridoborate: a complex with silver in a seesaw coordination geometry

The reaction of 2-acetylpyridine with silver(I) tetra­fluorido­borate leads to the discrete title complex, [Ag(C7H7NO)2]BF4, in the cation of which the Ag atom is coordinated by two 2-acetylpyridine ligands, each of which is N,O-bidentate, albeit with stronger bonding to the N atoms [Ag—N = 2.2018 (15) and 2.2088 (14) Å; Ag—O = 2.5380 (13) and 2.5454 (13) Å]. The four-coordinate Ag atom has a seesaw coordination geometry with a τ4 index of 0.51. The tetra­fluoridoborate anion is disordered over two orientations with 0.568 (10):0.432 (10) occupancies

Power limits and a figure of merit for stimulated Brillouin scattering in the presence of third and fifth order loss

We derive a set of design guidelines and a figure of merit to aid the engineering process of on-chip waveguides for strong Stimulated Brillouin Scattering (SBS). To this end, we examine the impact of several types of loss on the total amplification of the Stokes wave that can be achieved via SBS. We account for linear loss and nonlinear loss of third order (two-photon absorption, 2PA) and fifth order, most notably 2PA-induced free carrier absorption (FCA). From this, we derive an upper bound for the output power of continuous-wave Brillouin-lasers and show that the optimal operating conditions and maximal realisable Stokes amplification of any given waveguide structure are determined by a dimensionless parameter $\mathcal{F}$ involving the SBS-gain and all loss parameters. We provide simple expressions for optimal pump power, waveguide length and realisable amplification and demonstrate their utility in two example systems. Notably, we find that 2PA-induced FCA is a serious limitation to SBS in silicon and germanium for wavelengths shorter than 2200nm and 3600nm, respectively. In contrast, three-photon absorption is of no practical significance

Impact of nonlinear loss on Stimulated Brillouin Scattering

We study the impact of two-photon absorption (2PA) and fifth-order nonlinear loss such as 2PA-induced free-carrier absorption in semiconductors on the performance of Stimulated Brillouin Scattering devices. We formulate the equations of motion including effective loss coefficients, whose explicit expressions are provided for numerical evaluation in any waveguide geometry. We find that 2PA results in a monotonic, algebraic relationship between amplification, waveguide length and pump power, whereas fifth-order losses lead to a non-monotonic relationship. We define a figure of merit for materials and waveguide designs in the presence of fifth-order losses. From this, we determine the optimal waveguide length for the case of 2PA alone and upper bounds for the total Stokes amplification for the case of 2PA as well as fifth-order losses. The analysis is performed analytically using a small-signal approximation and is compared to numerical solutions of the full nonlinear modal equations